Authors
Aldor,Erd,Gaul,Kuhn,Leisch,Lenzhofer,Mlczoch,Peschorn,Tiso,Block,Balthazar,Beys,Bladt,Bruyneel,DeBacker,Derbaudrenghien,Dierickx,ElAllaf,Fautsch,Francois,Henuzet,Kornitzer,Leone,Prihadi,Renard,Tremblay,Cagan,Dvorak,Heinc,Jirmar,Kana,Klapal,Lupinek,Pidrman,Rybka,Semrad,Smid,Spinar,Svitil,Zeman,Hardt,Horgan,O'Callaghan,Sullivan,Taaffe,Walsh,Aalto,Eloranta,Hussi,Kala,Kohvakka,Korpilahti,Koskelainen,Lindstrom,Linna,Pietila,Raasakka,Saari,Saarinen,Savola,Aboukhalil,Adams,Aliot,Andre,Apffel,Baradat,Barreau,Basin,Bassand,Baudet,Baudier,Bayo,Beaufils,Beltran,"Ben Ahmed",Bergere,Berthou,Berzin,Bessede,Blanc,Bollaert,Bolte,Boschat,Boulenc,Boumal,Bourdon,Bouthillier,Bragrad,"Brandt, CM",Brehier,Cami,Carette,Cattan,Cavallaro,Cazaugade,Chassevent,Chareyre,Chaussinand,Choux,Citron,Coisne,Colin,Combe,Convert,Cornaert,Cornuau,Cotel,Coudray,Damiani,Daubeze,Dechamboux,Degand,Delabrouille,Dellinger,DeLuze,Demarcq,Dennetiere,Dewilde,Dickele,D'Hautefeuille,D'Ivernois,Dreyfuss,Dubois,Duc,Dujardin,Dulhoste,Elaerts,Elattare,Fadel,Fagart,Faitg,Fernandez,Fruchaud,Funck,Gabrielle,Gaillemin,Gallel,Galley,Galloux,Gateau,Gauthier,Gerin,Geslin,Godin,Goldstein,Gottwalles,Goralski,Grollier,Guerin,Guignon,Guillemin,Gully,Guy,Hannebicque,Heiligenstein,Hertault,Hiltger,Jacques,Janin-Manificat,Jarry,Joussen,Julien,Julliard,Katz,Ketelers,Khalife,Lafont,Lagorce,Landas,Lanfranchi,Lapandry,Lapeysonnie,Larque,Larroque,Lassabe,Lemetayer,Lepine,"Leroy, F
Leroy, O",Levy,Leymarie,Liandras,Librez,Lopez,Louis,"de Pontlevoye, L",Ly,Mangola,"Mansour, L
Mansour, M",Marseilles,Martelet,Mathurin,Meininger,Metzger,Mermet,Meyer,Michel,Michoux,Moisan,Morand,Mossaz,Mycinski,Nemitz,Olivier,Ollivier,Page,Pareathumby,Parisot,Petit,Pezard,Poirier,Pollet,Pousset,Pradies,Pugniet,Quiret,Rauscher,Raynal,Richard,Rivoal,Rocheman,Rondepierre,Rosant,Rouch,Roussel,Roussignol,Sadder,Sans,Serusclat,Sibille,Smolsky,Socolovsky,Sophys,Soulat,Stubei,Tavernier,Terville,Thery,Thieuleux,Tirkawai,Toffin,Tognet,Tran-Thanh,Trochu,Vaides,Vanzetto,Veyre,Villeger,Weber,Wolf,Zerah,Aggeli,Androulakis,Anthopoulos,Bakoulas,Christakos,Fotiadis,Foussas,Gazetopoulos,Hadjisavas,Karidis,Karras,Kelesidis,Koliopoulos,Koutmeridis,Koutsibanis,Kremastinos,Lefkos,Louvros,Mantas,Oikonomou,Papasteriadis,Papazachariou,Papazoglou,Sideris,Sinis,Skoufas,Spanou,Toutouzas,Vardas,Vogiatzi,Zacharoulis-Antonatos,Bernardi,Bini,Carta,Chiriatti,Coccolini,DelBene,Ieri,Leo,Marzilli,Ozsini,Palmieri,Papi,Pesola,Pettinati,"Anshelevich, C
Anshelevich, I
Anshelevich, M",Erglis,Gersamia,Gozite,Hansone,Kislyak,Kochkarev,Kozlov,Krage,Norko,Panichin,Verbovenko,Veze,Vilpore,Viva,Yakubaneca,Zarubina,Beissel,Erpelding,Bielak,Czestochowska,Demczuk,Dubinski,Dyduszynski,Gorski,Halaczkiewicz,Ilmurzynska,Janicki,Janion,Jaworska,Jedrzejowski,Kakol,Kolodziej,Kopaczewski,Kornacewicz-Jach,Kraska,Krzeminska-Pakula,Kuc,Kurowski,Lewandowska-Stanek,Malinski,Markiewicz,Modrzejewski,Nartowicz,Ostrzycki,Petelenz,Piwowarska,Prastowski,Regulski,Ronkowski,Sadowski,Sas,Skura,Swiatecka,Turkiewicz,Ujda,Wojciechowski,Zalewski,Carrageta,"Coelho, G
d'Almeida, C
dos Santos, C
Martins, CT
Lacerda, F
Leitao, G",Massa,Mendes,"Araujo, P",Providencia,"Luis, S",Seabra-Gomes,Silva,"Ribeiro, VGRI",Rodrigues,Rufino,Belenky,Bimenko,Boiarkin,Boitsov,Bondarenko,Brenner,Bzhelyanskaya,Duda,Dolnikovskaya,Ergorova,Fediay,Fialkovsky,Fomin,Fotianov,Freidlina,Gabriljanz,Gavrish,Goloschekin,Golovachev,Gubachev,Iliazova,Iniushin,Irklienko,Kompaniets,Kostenko,Kotkina,Kovanov,Kozlitin,Kuptsova,Lapin,Lepekhov,Loginovskaya,Maximova,Orlikova,Perminov,Pomogalova,Rifel,Ruksin,Sergeeva,Shwartz,Sintotsky,Sitnikova,Sorokin,Stefanenko,Stoliarova,Tashaeva,Timofeev,Tumarov,Tyrenko,Uliakhina,Ushakov,Valdenberg,Varshavsky,Vishnevsky,Zemskova,Chubuchna,Dykun,Dzholos,Ergorov,Goroborodko,Grishina,Kononenko,Korytko,Kraiz,Nesukay,Netiazhenko,Parkhomenko,Posokhova,Prudky,Rudenko,Shevchenko,Taschuk,Archer,Devlin,Keller,"Boyle, MC",Metcalfe,Pitts-Crick,Salathia,Signy,Vicent,Wray,"Akkal, A
Akkal, Z",Boissel,Bugnard,Brun,Cucherat,Foote,Guenaneche,Herve,Rodrigo,Leizorovicz,Maupas,Mercier,Quattrociocchi,Teppe,Thien,Varshavsky,Andre-Fouet,Coppere,Cucherat,Page,Boissel,Leizorovicz,Julian,Meier,Samana,Sleight,Tognoni,Victor,Bourguignon,Harpey,Leizorovicz
Citation
F. Aldor,erd,gaul,kuhn,leisch,lenzhofer,mlczoch,peschorn,tiso,block,balthazar,beys,bladt,bruyneel,debacker,derbaudrenghien,dierickx,elallaf,fautsch,francois,henuzet,kornitzer,leone,prihadi,renard,tremblay,cagan,dvorak,heinc,jirmar,kana,klapal,lupinek,pidrman,rybka,semrad,smid,spinar,svitil,zeman,hardt,horgan,o'Callaghan,sullivan,taaffe,walsh,aalto,eloranta,hussi,kala,kohvakka,korpilahti,koskelainen,lindstrom,linna,pietila,raasakka,saari,saarinen,savola,aboukhalil,adams,aliot,andre,apffel,baradat,barreau,basin,bassand,baudet,baudier,bayo,beaufils,beltran,"ben Ahmed",bergere,berthou,berzin,bessede,blanc,bollaert,bolte,boschat,boulenc,boumal,bourdon,bouthillier,bragrad,"brandt, Cm",brehier,cami,carette,cattan,cavallaro,cazaugade,chassevent,chareyre,chaussinand,choux,citron,coisne,colin,combe,convert,cornaert,cornuau,cotel,coudray,damiani,daubeze,dechamboux,degand,delabrouille,dellinger,deluze,demarcq,dennetiere,dewilde,dickele,d'Hautefeuille,d'Ivernois,dreyfuss,dubois,duc,dujardin,dulhoste,elaerts,elattare,fadel,fagart,faitg,fernandez,fruchaud,funck,gabrielle,gaillemin,gallel,galley,galloux,gateau,gauthier,gerin,geslin,godin,goldstein,gottwalles,goralski,grollier,guerin,guignon,guillemin,gully,guy,hannebicque,heiligenstein,hertault,hiltger,jacques,janin-manificat,jarry,joussen,julien,julliard,katz,ketelers,khalife,lafont,lagorce,landas,lanfranchi,lapandry,lapeysonnie,larque,larroque,lassabe,lemetayer,lepine,"leroy et al., Effect of 48-h intravenous trimetazidine on short- and long-term outcomes of patients with acute myocardial infarction, with and without thrombolytictherapy - A double-blind, placebo-controlled, randomized trial, EUR HEART J, 21(18), 2000, pp. 1537-1546
Citations number
17
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
EUROPEAN HEART JOURNAL
ISSN journal
0195668X
→ ACNP
Volume
21
Issue
18
Year of publication
2000
Pages
1537 - 1546
Database
ISI
SICI code
0195-668X(200009)21:18<1537:EO4ITO>2.0.ZU;2-W
Abstract
Aims To compare the effect of trimetazidine (TMZ) versus placebo administer
ed during the acute phase of myocardial infarction on long- and short-term
mortality.
Methods and Results EMIP-FR (European Myocardial Infarction Project-Free Ra
dicals) was a prospective, double-blind, European multicentre trial in whic
h 19 725 patients, presenting symptoms of acute myocardial infarction withi
n the previous 24 h were randomized. Stratification was according to thromb
olytic therapy (56%) or not (44%). An intravenous bolus injection of trimet
azidine (40 mg) was given just before or simultaneously with thrombolysis,
followed by continuous infusion (60 mg . 24 h(-1)) for 48 h. Overall, no di
fference was found between trimetazidine and placebo for the main end-point
, short-term (35-day) mortality, (P=0.98) in an intention-to-treat analysis
. This was the result of opposing trends in the two strata. Thrombolysed pa
tients showed a tendency towards more short-term deaths with trimetazidine,
compared to placebo (trimetazidine: 11.3%, placebo: 10.5%, P=0.15) and non
-thrombolysed patients the converse (trimetazidine: 14.0%, placebo: 15.1%,
P=0.14). In a perprotocol analysis the beneficial effect of trimetazidine f
ar non-thrombolysed patients became statistically significant (trimetazidin
e: 13.3%, placebo: 15.1%, P=0.027).
Conclusion Trimetazidine does not reduce mortality in patients undergoing t
hrombolytic therapy; however, it might have some beneficial effect for non-
thrombolysed patients. (Eur Heart J 2000; 21: 1537-1546) (C) 2000 The Europ
ean Society of Cardiology.