S. Varani et al., The incidence of cytomegalovirus (CMV) antigenemia and CMV disease is reduced by highly active antiretroviral therapy, EUR J EPID, 16(5), 2000, pp. 433-437
Citations number
24
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Cytomegalovirus (CMV) infection was one of the most common opportunistic in
fections in AIDS patients, leading to blindness or life-threatening disease
in about 40% of patients in the later stages of AIDS before highly active
antiretroviral therapy (HAART). In a retrospective multicenter study we inv
estigated the incidence of CMV retinitis and organ involvement in Northern
Italy before (1995 and 1996) and after the introduction of HAART (1997 and
1998) as well as the data regarding CMV antigenemia. We found a sharp drop
in the incidence of CMV disease in AIDS patients as well as a decline in th
e incidence of relapses of CMV-disease after the widespread introduction of
HAART. Moreover, there was a decrease in the incidence of antigenemia-posi
tive cases in AIDS patients in the era of HAART and the median CMV viral lo
ad was significantly higher in patients who didn't receive HAART than in pa
tients who received HAART (p = 0.001, t test).