LIPID-A AND RELATED-COMPOUNDS .33. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF N-ACYLATED L-SERINE OR L-THREONINE-CONTAINING D-GLUCOSAMINE DERIVATIVES AS MIMICS OF LIPID-A DISACCHARIDE

Authors
MIYAJIMA K GOMI N IKEDA K ACHIWA K
Citation
K. Miyajima et al., LIPID-A AND RELATED-COMPOUNDS .33. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF N-ACYLATED L-SERINE OR L-THREONINE-CONTAINING D-GLUCOSAMINE DERIVATIVES AS MIMICS OF LIPID-A DISACCHARIDE, Chemical and Pharmaceutical Bulletin, 45(6), 1997, pp. 1089-1093
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
6
Year of publication
1997
Pages
1089 - 1093
Database
ISI
SICI code
0009-2363(1997)45:6<1089:LAR.SA>2.0.ZU;2-Z
Abstract
Four novel N-acylated L-serine or L-threonine-containing non-phosphory lated D-glucosamine derivatives structurally corresponding to the lipi d A disaccharide backbone were synthesized, Compounds 2, 3 and 4 exhib ited potent mitogenic activity. Among the threonine-linked lipid A ana logs (1-3), serine-linked lipid A analogs (4-6) and homoserine-linked lipid A analogs (7-9), the serine compounds (4, 6) showed the most pot ent mitogenic activity.