STUDIES ON NEPALESE CRUDE DRUGS .23. ON THE DITERPENOID CONSTITUENTS OF THE AERIAL PARTS OF SCUTELLARIA-GROSSA WALL

Authors
OHNO A KIZU H TOMIMORI T
Citation
A. Ohno et al., STUDIES ON NEPALESE CRUDE DRUGS .23. ON THE DITERPENOID CONSTITUENTS OF THE AERIAL PARTS OF SCUTELLARIA-GROSSA WALL, Chemical and Pharmaceutical Bulletin, 45(6), 1997, pp. 1097-1100
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
6
Year of publication
1997
Pages
1097 - 1100
Database
ISI
SICI code
0009-2363(1997)45:6<1097:SONCD.>2.0.ZU;2-Z
Abstract
From the aerial parts of Scutellaria grossa, a new neoclerodane diterp ene named scutegrossin A has been isolated together with five known ne oclerodane diterpenes, jodrellin B, scutecolumnin A, scutalsin, scutec yprol B and scutalbin B.The structure of a new compound has been deter mined by spectroscopic and chemical methods as (11S,13S,16S,19R)-6 alp ha-O-acetyl-19-O-[(E)-2-methyl-2-butenoyl]-2 alpha,19;4 ;11,16;15,16-t etraepoxy-14-neoclerodene-6,19-diol. In addition, the absolute stereoc hemistry of 2-methylbutanoyl group of scutecolumnin A and scutalbin B has been ascertained to be the S form.