C2PA, a new protein expressed during mouse spermatogenesis

C2PA is a novel protein that contains a C2 membrane binding domain, a PDZ p rotein/protein interaction domain, and an ATP/GTP binding domain. C2PA is e xpressed during embryogenesis from 8.5 days post-coitum (dpc) until birth. After birth, C2PA expression is mainly observed in the post-natal and adult testis, During spermatogenesis, C2PA transcripts are specifically observed in the spermatocytes, whereas spermatogonia and spermatids are negative. T aken together, these results suggest that C2PA might be involved in cell si gnaling pathways occurring during spermatogenesis. (C) 2000 Federation of E uropean Biochemical Societies. Published by Elsevier Science B.V. All right s reserved.