The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains

Authors
Niijima, H Nagao, M Nakajima, M Takatori, T Iwasa, M Maeno, Y Koyama, H Isobe, I
Citation
H. Niijima et al., The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains, FOREN SCI I, 112(2-3), 2000, pp. 171-178
Citations number
16
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
FORENSIC SCIENCE INTERNATIONAL
ISSN journal
03790738 → ACNP
Volume
112
Issue
2-3
Year of publication
2000
Pages
171 - 178
Database
ISI
SICI code
0379-0738(20000814)112:2-3<171:TEOSAS>2.0.ZU;2-V
Abstract
One sarin-like and one soman-like organophosphorus agent [bis(isopropyl met hyl)phosphonate, BIMP and bis(pinacolyl methyl)phosphonate, BPMP] were inje cted intravenously (iv) in rats. An increase in the tyrosine phosphorylatio n of several proteins in the cytosol fraction of the brain was observed. Ac tivation of c-Jun N-terminal kinase (JNK) and slight activation of mitogen- activated protein kinase (MAPK) in the cytosol were also observed. The acti vation of these enzymes may be related to the high toxicity of these nerve agents. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.