A child with ALL and ETV6/AMLI fusion on a chromosome 12 due to an insertion of AMLI and loss of ETV6 from the homolog involved in a t(12;15)(p13;q15)

Authors
Reddy, KS Yang, XJ Mak, L Wang, SR Johnston, M
Citation
Ks. Reddy et al., A child with ALL and ETV6/AMLI fusion on a chromosome 12 due to an insertion of AMLI and loss of ETV6 from the homolog involved in a t(12;15)(p13;q15), GENE CHROM, 29(2), 2000, pp. 106-109
Citations number
12
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
GENES CHROMOSOMES & CANCER
ISSN journal
10452257 → ACNP
Volume
29
Issue
2
Year of publication
2000
Pages
106 - 109
Database
ISI
SICI code
1045-2257(200010)29:2<106:ACWAAE>2.0.ZU;2-D
Abstract
A 4-year-old boy was found to have acute lymphoblastic leukemia characteriz ed by a t(12;15)(p13;q15). FISH investigation using a TEL(ETV6)/AML1 probe detected a fusion signal in 98% of the interphase cells. Sequential FISH on a G-banded slide showed a fusion signal on an apparently normal chromosome 12 and AML1 signals on chromosomes 21. The EN6 was deleted from the chromo some 12 involved in the t(12;15). These results are best explained as an in sertion of AML1 into TEL on one chromosome arm 12p and loss of ETV6 from th e chromosome 12 involved in the t(12; 15). (C) 2000 Wiley-Liss, Inc.