Although numbers are still small and followup is often limited, female orth
otopic bladder reconstruction has been shown to provide excellent, near-nor
mal voiding and storage function in selected patients, and its popularity h
as been growing over the last decade. The true role of this form of surgery
, however, is not yet fully established. This paper discusses the indicatio
ns for patient selection, operative technique and outcome of female bladder
substitution. Outcome is equivalent to that seen in male patients, althoug
h in some series there is a higher rate of voiding dysfunction requiring in
termittent self-catheterization. Although further data regarding urethral r
ecurrence rates are awaited, it would seem that with careful patient select
ion and operative technique, cancer surgery may not be compromised. Functio
nal results have been excellent and patient satisfaction is very high. Prov
ided there is a functional external sphincter and tumor margins can be safe
ly cleared, this form of surgery offers patients the best opportunity to pr
eserve quality of life following cystectomy.