Two new gene cassettes, drf17 (for trimethoprim resistance) and aadA4 (forspectinomycin/streptomycin resistance), inserted in an Escherichia coli class 1 integron

Authors
Chang, CY Chang, LL Chang, YH Lee, TM Li, YH Chang, SF
Citation
Cy. Chang et al., Two new gene cassettes, drf17 (for trimethoprim resistance) and aadA4 (forspectinomycin/streptomycin resistance), inserted in an Escherichia coli class 1 integron, J ANTIMICRO, 46(1), 2000, pp. 87-89
Citations number
10
Categorie Soggetti
Pharmacology,Microbiology
Journal title
Journal of antimicrobial chemotherapy
ISSN journal
03057453 → ACNP
Volume
46
Issue
1
Year of publication
2000
Pages
87 - 89
Database
ISI
SICI code
Abstract
Two new gene cassettes, dfr17 and aadA4, inserted in a class 1 integron of Escherichia coli EC107, are described here. The dfr17 cassette encodes trim ethoprim resistance and has 91% identity with the dfrVII dihydrofolate redu ctase gene. The aadA4 cassette confers resistance to spectinomycin and stre ptomycin and shows 94% identity with the aadA3 gene. The integron carrying the dfr17 and aadA4 cassettes was located on a conjugative plasmid, pEC1072 .