In vitro activity of telithromycin (HMR 3647) and seven other antimicrobial agents against anaerobic bacteria

We assessed the in vitro activity of telithromycin (HMR 3647) and seven oth er antimicrobials against 292 strains of obligately anaerobic bacteria. MIC s were determined with the microdilution technique and Wilkins-Chalgren bro th according to DIN 58940-83. MIC50/MIC(90)s (mg/L) for telithromycin were 4/4 for Bacteroides fragilis, Bacteroides ovatus and Bacteroides thetaiotao micron, 2/4 for Fusobacterium son. and Bilophila wadsworthia, 2/2 for Bacte roides caccae, 1/4 for Bacteroides vulgatus, 0.25/4 for Prevotella spp., le ss than or equal to 0.03/0.5 for Clostridium spp, and 0.125/4 for Peptostre ptococcus spp.