Prognostic markers in patients with typical bronchial carcinoid tumors

Typical bronchial carcinoids are usually considered fairly benign tumors. M etastases do however occur, and up to 10% of the patients ultimately die fr om their disease. To identify prognostic markers, we immunostained 43 typic al bronchial carcinoids with antibodies against 8 possibly relevant hormone s, oncogenes, tumor suppressor genes, adhesion molecules, and proliferation markers. Altogether 12 patients (28%) had metastatic disease, of whom 10 h ad regional lymph node metastases at diagnosis. Distant metastases have occ urred in 5 patients (12%); all of these have died from their disease. Patie nts with high expression of Ki-67 had shorter survival time (P < 0.01). Non e of the immunostained hormones correlated to distant metastases or shorter survival time, but gastrin-releasing peptide correlated to metastatic dise ase (P < 0.05). All patients who died had CD44-negative tumors (P < 0.001). Nuclear nm23 staining correlated to decreased risk for metastatic disease and distant metastases per se (P < 0.01). Bcl-2 and p53 were associated wit h increased risk for distant metastases (P < 0.05 and P < 0.01, respectivel y). We conclude that some patients with typical bronchial carcinoids die fr om their disease and that gastrin-releasing peptide, Bcl-2, and p53 may be of importance for the malignant transformation of the tumor. Moreover, CD44 , nm23, and Ki-67 may give valuable prognostic information and help identif y the patients at risk of disease-related death.