Future directions in the management of pain by intraspinal drug delivery

Management of pain by intraspinal delivery of drugs enables physicians to t arget specific sites of action. While this novel approach is gaining increa sing use, well-designed studies are needed. A major limitation is the lack of published information on existing drugs used for intrathecal delivery. ( The strengths and weaknesses of this information are reviewed in the accomp anying literature review article.) Promising agents such as bupivacaine, hy dromorphone, and morphine/clonidine combinations warrant further research i n large prospective (ideally randomized and double-blind) clinical safety a nd efficacy studies. These studies may provide data for pain management gui delines, such as those included in the preceding paper: Research must also add,pss issues of formulation, chemical stability/conpatibility pharmacokin etics, and toxicology during clinical development and cl,drug approval. Fin ally, more basic studies and early phase trials of other potential agents. intrathecal pain management (e.g., gabapentin) are needed (C) U.S. Cancer P ain Relief Committee, 2000.