Sjogren's syndrome (SS) is a chronic autoimmune disease mainly characterize
d by dry mouth and dry eyes due to an inflammatory process in the exocrine
glands. We describe a pair of Caucasian monozygotic twin sisters and their
mother, all having primary SS. The twins had very similar clinical presenta
tion and almost identical serological data, and histological examination of
lower labial salivary glands gave a focus score of 3 in both twins. We als
o present their family medical history, which shows aggregation of immunolo
gical disorders among family members, although the twins and their mother w
ere the only individuals with primary SS.