A 53-year-old female had clinical and laboratory findings suggestive o
f Gushing's syndrome, In contrast to the Gushing's syndrome caused by
cortical adenoma, a high level of urinary 17-ketosteroids (17-KS) was
also noted, Imaging studies revealed a right adrenal tumor, Right adre
nectomy was performed; the surgical specimen revealed a black adenoma
consisting of compact cells with numerous pigments which seemed to be
lipofuscin in nature, The present case indicates that black adenoma as
well as adrenocortical carcinoma should be suspected, when patients w
ith Gushing's syndrome show an increased level of urinary 17-KS excret
ion.