CRYOFIBRINOGENEMIA WITH POLYARTHRALGIA, RAYNAUDS-PHENOMENON AND ACRALULCER IN A PATIENT WITH GRAVES-DISEASE TREATED WITH METHIMAZOLE

Cryofibrinogenemia is a cryopathy in which hypersensitivity to cold is a prominent feature, Cryofibrinogenemia developed in an 18-year-old J apanese female patient during methimazole therapy for Graves' disease, She developed cryopathy (livedo reticularis, Raynaud's phenomenon and acral ulcer) and polyarthralgia during methimazole therapy, and we de tected cryofibrinogen in her plasma. Her symptoms resolved after admin istration of prostaglandins and anticoagulants, Several reports indica te that methimazole therapy induces autoantibody-related disease. In t he present case, we cannot exclude the possibility that methimazole th erapy contributed to the cryofibrinogenemia.