Cardiopulmonary cerebral resuscitation using emergency cardiopulmonary bypass, coronary reperfusion therapy and mild hypothermia in patients with cardiac arrest outside the hospital
K. Nagao et al., Cardiopulmonary cerebral resuscitation using emergency cardiopulmonary bypass, coronary reperfusion therapy and mild hypothermia in patients with cardiac arrest outside the hospital, J AM COL C, 36(3), 2000, pp. 776-783
Citations number
40
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
OBJECTIVES The purpose of this study was to evaluate the efficacy of an alt
ernative cardiopulmonary cerebral resuscitation (CPCR) using emergency card
iopulmonary bypass (CPB), coronary reperfusion therapy and mild hypothermia
.
BACKGROUND Good recovery of patients with out-of-hospital cardiac arrest is
still inadequate. An alternative therapeutic method for patients who do no
t respond to conventional CPCR is required.
METHODS A prospective preliminary study was performed in 50 patients with o
ut-of-hospital cardiac arrest meeting the inclusion criteria. Patients were
treated with standard CPCR and, if there was no response, by emergency CPB
plus intra-aortic balloon pumping. Immediate coronary angiography for coro
nary reperfusion therapy was performed in patients with suspected acute cor
onary syndrome. Subsequently, in patients with systolic blood pressure abov
e 90 mm I-Ig and Glasgow coma scale score of 3 to 5, mild hypothermia (34 d
egrees C for at least two days) was induced by coil cooling. Neurologic out
come was assessed by cerebral performance categories at hospital discharge.
RESULTS Thirty-six of the 50 patients were treated with emergency CPB, and
30 of 39 patients who under;vent angiography suffered acute coronary artery
occlusion. Return of spontaneous circulation and successful coronary reper
fusion were achieved in 92% and 87%, respectively. Mild hypothermia could b
e induced in 23 patients, and 12 (52%) of them showed good recovery. Factor
s related to a good recovery were cardiac index in hypothermia and the pres
ence of serious complications with hypothermia or CPB.
CONCLUSIONS The alternative CPCR demonstrated an improvement in the inciden
ce of good recovery. Based upon these findings, randomized studies of this
hypothermia are needed. (C) 2000 by the American College of Cardiology.