The genotoxic effect of copper(II) complexes by Salmonella mutagenicity assay

Authors
Szabova, E Mikulasova, M Cerny, J Melnik, M
Citation
E. Szabova et al., The genotoxic effect of copper(II) complexes by Salmonella mutagenicity assay, J TR MICROP, 18(3), 2000, pp. 425-430
Citations number
11
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF TRACE AND MICROPROBE TECHNIQUES
ISSN journal
07334680 → ACNP
Volume
18
Issue
3
Year of publication
2000
Pages
425 - 430
Database
ISI
SICI code
0733-4680(2000)18:3<425:TGEOCC>2.0.ZU;2-7
Abstract
Salmonella typhimurium reverse mutation assay (Ames test) was used for dete cting the mutagenicity and antimutagenicity of Cu(II) acetylsalicylate as w ell as his ronicol adduct. No significant increase in the number of His+ re vertant colonies could by observed in the range of concentrations tested wh ether in the absence or in the presence of a metabolic activation with Salm onella typhimurium TA97, TA98, TA100 and TA102. Cu(II) compounds statistica lly significantly decreased the number of revertants induced by 2-aminoanth racene and 2-aminofluorene.