In this review we focus on aspects of the virus-specific cellular immune re
sponse, although we should point out that all the components of the innate
and adaptive immune response are likely to play a role in successful contro
l of hepatitis B virus (HBV) infection. We concentrate particularly on the
relevance of the polyclonality and multispecificity of the HBV-specific cyt
otoxic T cell response to its antiviral activity. In this context, we discu
ss the possible role of viral escape mutations and highlight evidence from
other models of the benefit of multispecificity in antiviral responses. We
stress the contribution of CD4 help for effective CD8 responses and raise t
he possibility that HBV may produce factors inhibiting the antiviral respon
se.