Tp53 gene therapy: a key to modulating resistance to anticancer therapies?

Authors
Chang, EH Pirollo, KF Bouker, KB
Citation
Eh. Chang et al., Tp53 gene therapy: a key to modulating resistance to anticancer therapies?, MOL MED TOD, 6(9), 2000, pp. 358-364
Citations number
72
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
MOLECULAR MEDICINE TODAY
ISSN journal
13574310 → ACNP
Volume
6
Issue
9
Year of publication
2000
Pages
358 - 364
Database
ISI
SICI code
1357-4310(200009)6:9<358:TGTAKT>2.0.ZU;2-M
Abstract
Abnormalities in the p53 tumor suppressor have been identified in over 60% of human cancers. The status of p53 within tumor cells has been proposed to be one of the major determinants of the response to anticancer therapies. In this review we examine the relationship between functional p53 and sensi tivity, or resistance, to chemotherapy and radiotherapy. We also discuss th e potential of current gene-therapy approaches to restore functional p53 to tumors as a means of modulating the effects of radiation and chemotherapy.