New antifungal agents that inhibit the growth of Candida species: Dichlorinated 8-quinolinols

Five dichlorinated 8-quinolinols (2,5- 5,6-, 3,5-, 3,7-, and 4,5-dichloro-8 -quinolinol) were tested against Candida albicans and C. Tropicalis in Sabo uraud dextrose broth with and without bovine serum. The 5,6-, 3,5-, and 3,7 -dichloro-8-quinolinols proved to be more effective than the control, 5-flu orocytosine. In cytotoxicity tests employing baby hamster kidney (BHK) cell s, all test agents proved to be more cytotoxic than the control. However, t he minimum inhibitory concentration (MIC) of 3,5-dichloro-8-quinolinol to b oth fungi was only one tenth the cytotoxic dose, suggesting that the compou nd may be useful as a topical or systemic antifungal agent.