Thrombin signalling and protease-activated receptors

Authors
Citation
Sr. Coughlin, Thrombin signalling and protease-activated receptors, NATURE, 407(6801), 2000, pp. 258-264
Citations number
64
Categorie Soggetti
Multidisciplinary,Multidisciplinary,Multidisciplinary
Journal title
NATURE
ISSN journal
00280836 → ACNP
Volume
407
Issue
6801
Year of publication
2000
Pages
258 - 264
Database
ISI
SICI code
0028-0836(20000914)407:6801<258:TSAPR>2.0.ZU;2-M
Abstract
How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with th e coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.