Melanocortins and body weight: a tale of two receptors

Authors
Cummings, DE Schwartz, MW
Citation
De. Cummings et Mw. Schwartz, Melanocortins and body weight: a tale of two receptors, NAT GENET, 26(1), 2000, pp. 8-9
Citations number
18
Categorie Soggetti
Molecular Biology & Genetics
Journal title
NATURE GENETICS
ISSN journal
10614036 → ACNP
Volume
26
Issue
1
Year of publication
2000
Pages
8 - 9
Database
ISI
SICI code
1061-4036(200009)26:1<8:MABWAT>2.0.ZU;2-I
Abstract
The phenotypes of mice lacking melanocortin-3 (Mcr3) and melanocortin4 rece ptors (Mc4r) demonstrate that these isoforms reduce body weight through dis tinct and complementary mechanisms. Mc4r regulates food intake and possibly energy expenditure, whereas Mc3r influences feed efficiency and the partit ioning of fuel stores into fat.