Protein dynamics from NMR

This review surveys recent investigations of conformational fluctuations of proteins in solution using NMR techniques. Advances in experimental method s have provided more accurate means of characterizing fast and slow interna l motions as well as overall diffusion. The information obtained from NMR d ynamics experiments provides insights into specific structural changes or c onfigurational energetics associated with function. A variety of applicatio ns illustrate that studies of protein dynamics provide insights into protei n-protein interactions, target recognition, ligand binding, and enzyme func tion.