THE EFFECT OF ISOPTIN SR ON BLOOD-PRESSURE, HEART FUNCTION AND HYPERTROPHY OF LEFT-VENTRICLE OF HYPERTENSIVE PATIENTS

Isoptin SR was used in 65 essential hypertensive patients. 240mg Isopt in SR (German Knoll Pharmaceutical company) per day was used in group A (35 cases) for 6 weeks, and in group B (30 cases) for 24 weeks, BP i n group A and B decreased obviously in the first and second week after treatment. Marked effective rate and total effective rate were 65.7% and 74.3% respectively in group A, and 70.0% and 83.3% in group B. The re were no significant changes of HR in group A before and after treat ment while there was a decrease of HR in group B (P < 0.001). Left atr ium (LA) decreased after 6 weeks in group A with an obvious increase o f E/A ratio. There was significant decrease in LA, increase in E/A rat io, regression of IVS, LVPW and LVMI, but no changes in SV, CO, LVEF a fter 24 weeks of treatment of Isoptin SR in group B. E / A ratio was v ery sensitive and occurred earliest both in group A and group B. Side effects such as headache, dizziness, constipation, insomnia, periphera l oedema, sinus bradycardia occurred mainly in the first week of treat ment. These symptoms disappeared gradually in the course of continued administration of Isoptin SR.