Non-Hodgkin's lymphoma of the uterus and CNS

We report a case of a non-Hodgkin's lymphoma of the uterus and central nerv ous system in an 8-year-old female. The neurologic signs included blurred v ision, neck stiffness, and walking difficulties but no abdominal problems. She deteriorated further, and repeated lumbar punctures revealed the presen ce of malignant cells in the cerebrospinal fluid, A repeated ultrasound sca n of the abdomen demonstrated a markedly enlarged uterus, Biopsy revealed B -cell non-Hodgkin's lymphoma, Treatment according to the Berlin-Frankfurt-M unster protocol was initiated, but she developed hyperventilation syndrome and required mechanical ventilation. Her condition improved after 1 week bu t then deteriorated again, and despite additional chemotherapy she develope d myelosuppression and septicemia with multiresistant Klebsiella pneumoniae and eventually died 13 months after her first admission to the hospital, N o clinical or laboratory signs of relapse were evident at the time of death , (C) 2000 by Elsevier Science Inc. All rights reserved.