Group A rotaviruses are a major cause of severe gastroenteritis in children
under 4 years of age worldwide. Group A rotaviruses have been identified i
n many animal and bird species; they are antigenically complex, and multipl
e serotypes infect humans. Reassortant rotavirus vaccines are now available
that confer protection against severe illness due to rotavirus serotypes G
1-4. Before vaccines are introduced, it is necessary to establish their eff
icacy and to establish a baseline for future surveillance strategies. The p
urpose of the present review is to describe current knowledge of the divers
ity of rotavirus in Taiwan. The present review is based on the available pu
blished studies and data from China Medical College Hospital (Taiwan). In T
aiwan, rotavirus has been detected year-round, with the epidemic peak swing
ing from November-December in 1984 to January-March in 1988-95 and then bac
k to December-March in 1996-99. Most affected patients are under 2 years of
age. Only group A rotavirus has been found. Neither group B nor group C ro
tavirus have been identified. G1 strains have been the predominant strains
except for the year 1992-93, when G2 strains were prevalent. There has been
no G4 strain detected in published studies. The electropherotype 'baba' ha
s been observed every year. Five other electropherotypes have been sporadic
ally found. Half of the strains that have been studied were genotype P[8] a
nd their VP7 serotype was G1 or G3. All genotype P[4] strains have shown se
rotype G2. It is expected that the reassortant rotavirus vaccine will be ef
fective in prevention of severe illness caused by rotavirus in Taiwan.