We present an analysis and results on the homogeneous nucleation of a dislo
cation loop under stress in a perfect crystal. By using a variational bound
ary integral method in the Peierls-Nabarro framework, we have determined th
e saddle-point configurations of embryonic dislocation loops and their asso
ciated activation energies under stress levels up to the ideal shear streng
th. The high-energy barriers under the usual levels of applied shear stress
es, differing markedly from the ideal shear strength, confirm the widely he
ld view that thermal motion should play no role in such nucleation. The res
ult provides means for more definitive solutions elf fundamental problems i
nvolving homogeneous nucleation of dislocation loops and has significant im
plications for models based on the mechanism of nucleation of dislocations
from a perfect crystal.