In the normal state, the out-of-plane resistivity rho(c) of high-quality Bi
2Sr2CuO6+delta single crystals shows an anomalously large negative magnetor
esistance in magnetic fields up to 28 T. This phenomenon corresponds to a s
uppression of the increase in rho(c) with decreasing temperatures as observ
ed in high-T-c superconductors above the critical temperature T-c. In contr
ast to the magnetoresistance in the superconducting state, this normal-stat
e out-of-plane magnetoresistance is independent of the field orientation (p
erpendicular and parallel to the CuO planes). This isotropic response point
s to the importance of spin effects on the pseudogap in the normal state, w
hereas the highly anisotropic response of the superconducting state is due
to orbital effects.