NEW METHODS OF RESOLUTION AND ENRICHMENT OF ENANTIOMERIC EXCESSES OF 1,1'-BI-2-NAPHTHOL

Partial resolution of racemic 1,1'-bi-2-naphthol (1) was readily achie ved to obtain enriched (scalemic) 1 using (S)-proline (2). The structu re of the complex 3 formed between 1 (2 equiv) and (S)-proline (1 equi v) was characterized by an X-ray diffraction method. Enantiomeric exce sses of the incompletely resolved 1 were enriched to obtain essentiall y pure (R)- and (S)-1 following a simple procedure using B(OH)(3) an T MEDA.