LEWIS ACID-PROMOTED COUPLING REACTIONS OF ACID-CHLORIDES WITH ORGANOALUMINUM AND ORGANOZINC REAGENTS

Authors
ARISAWA M TORISAWA Y KAWAHARA M YAMANAKA M NISHIDA A NAKAGAWA M
Citation
M. Arisawa et al., LEWIS ACID-PROMOTED COUPLING REACTIONS OF ACID-CHLORIDES WITH ORGANOALUMINUM AND ORGANOZINC REAGENTS, Journal of organic chemistry, 62(13), 1997, pp. 4327-4329
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
62
Issue
13
Year of publication
1997
Pages
4327 - 4329
Database
ISI
SICI code
0022-3263(1997)62:13<4327:LACROA>2.0.ZU;2-5
Abstract
An efficient synthesis of alpha,beta-unsaturated ketones by the reacti on of acid chlorides with trialkylaluminum (1/3 mole equiv) in the pre sence of AlCl3 (1 mol equiv) is described. Dialkylzincs were also usef ul and are easier to prepare than trialkylaluminum. Reaction of RCOCl with R'AlCl2 or R-2'AlCl gave R'COR, without AlCl3, in high yield.