Geropharmacology for the rheumatologist

Drug administration to older patients with rheumatic disease is a challenge because they are more likely to have adverse drug reactions compared with younger patients. Elderly patients are at risk for adverse drug effects bec ause they often have multiple acute and chronic illnesses and are on severa l prescription and over-the-counter medications. This article will enhance the practitioner's understanding of how disease and age modulate the pharma cokinetics and pharmacodynamics of medications commonly prescribed for rheu matic disorders. Minimizing the number of drugs prescribed, starting medica tions at low doses and increasing slowly, and monitoring for toxicity are e specially important in the elderly. With judicious use of medications, the quality of life of older patients with rheumatic disease can be enhanced.