A new antitumor isoquinoline alkaloid from the marine nudibranch Jorunna funebris

Authors
Fontana, A Cavaliere, P Wahidulla, S Naik, CG Cimino, G
Citation
A. Fontana et al., A new antitumor isoquinoline alkaloid from the marine nudibranch Jorunna funebris, TETRAHEDRON, 56(37), 2000, pp. 7305-7308
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
37
Year of publication
2000
Pages
7305 - 7308
Database
ISI
SICI code
0040-4020(20000908)56:37<7305:ANAIAF>2.0.ZU;2-C
Abstract
A new dimeric isoquinoline alkaloid, jorumycin (3), has been isolated from the skin and the mucus of the Pacific nudibranch Jorunna funebris. The stru cture has been fully elucidated on the grounds of ESMS data and of an exten sive 2D NMR analysis. The cytotoxicity of 3 was evaluated against various h uman cancer cell lines and was found to be slightly less potent than Et 743 (2). (C) 2000 Elsevier Science Ltd. All rights reserved.