Synthetic routes to NEtXaa(4)-cyclosporin A derivatives as potential anti-HIV I drugs

Authors
Hubler, F Ruckle, T Patiny, L Muamba, T Guichou, JF Mutter, M Wenger, R
Citation
F. Hubler et al., Synthetic routes to NEtXaa(4)-cyclosporin A derivatives as potential anti-HIV I drugs, TETRAHEDR L, 41(37), 2000, pp. 7193-7196
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
37
Year of publication
2000
Pages
7193 - 7196
Database
ISI
SICI code
0040-4039(20000909)41:37<7193:SRTNAD>2.0.ZU;2-Z
Abstract
An efficient synthesis in 10 steps and overall yields up to 27% of NEtXaa(4 )-cyclosporin A derivatives (Xaa = Leu, Val, Ile, Thr) starting from cyclos porin A is described. Biological activities of the new analogues show promi sing results for the design of cyclosporin derivatives exhibiting non-immun osuppressive and anti-HIV activity. (C) 2000 Elsevier Science Ltd. All righ ts reserved.