A practical asymmetric synthesis of alpha-methyl alpha-amino acids using achiral Cu-salen complex as a phase transfer catalyst

Authors
Belokon', YN Davies, RG North, M
Citation
Yn. Belokon' et al., A practical asymmetric synthesis of alpha-methyl alpha-amino acids using achiral Cu-salen complex as a phase transfer catalyst, TETRAHEDR L, 41(37), 2000, pp. 7245-7248
Citations number
32
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
37
Year of publication
2000
Pages
7245 - 7248
Database
ISI
SICI code
0040-4039(20000909)41:37<7245:APASOA>2.0.ZU;2-X
Abstract
The asymmetric C-alkylation of N-benzylidene alanine methyl ester has been achieved using a copper(II) (salen) complex as an asymmetric phase transfer catalyst and provides a practical synthesis of alpha-methyl alpha-amino ac ids with up to 86% enantiomeric excess. (C) 2000 Elsevier Science Ltd. All rights reserved.