Solid-phase synthesis of 2-aminoimidazolinones

Authors
Drewry, DH Ghiron, C
Citation
Dh. Drewry et C. Ghiron, Solid-phase synthesis of 2-aminoimidazolinones, TETRAHEDR L, 41(36), 2000, pp. 6989-6992
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
36
Year of publication
2000
Pages
6989 - 6992
Database
ISI
SICI code
0040-4039(20000902)41:36<6989:SSO2>2.0.ZU;2-H
Abstract
The synthesis of 2-aminoimidazolinones from resin-bound amino acids is desc ribed. Reaction of resinbound amino acids with isothiocyanates followed by treatment of the thioureas with Mukaiyama's reagent afforded the correspond ing carbodiimides, which reacted with amines to give 2-aminoimidazolinones in good yield and purity through a cyclization reaction that cleaves the pr oduct from the resin. (C) 2000 Elsevier Science Ltd. All rights reserved.