Second primary malignancies associated with renal cell carcinoma: Influence of histologic type

Objectives. This study was performed to determine which histologic types of renal cell carcinoma have an association with a second primary malignancy. Methods. Seven hundred sixty-three patients underwent an operation for rena l cell carcinoma between July 1989 and January 1999. The incidence of antec edent, synchronous, or subsequent second malignancies was determined. Stati stical tests based on the Poisson model were used to compare the observed n umber of subsequent malignancies developing after a diagnosis of renal cell carcinoma with the expected number calculated using the 1973 to 1994 U.S. Surveillance, Epidemiology, and End Results age, race, gender, and calendar -year specific incidence rates. Results. Second primary malignancies were present in 209 of 763 (27.4%) pat ients, with prostate, breast, colon, and bladder cancer and non-Hodgkin's l ymphoma being the five most common second malignancies. The other malignanc ies were antecedent in 118 cases (44.5%), synchronous in 104 cases (39.2%), and subsequent in 43 cases (16.2%). Patients with papillary renal cell car cinoma were at increased risk of developing bladder cancer (standardized in cidence ratio [SIR] 6.5, P = 0.038). Men with papillary renal cell carcinom a were also at increased risk of developing prostate cancer (SIR 2.8, P = 0 .035). Conclusions. There is an increased risk of subsequent bladder and prostate cancer in patients with papillary renal cell carcinoma. UROLOGY 56: 399-403 , 2000. (C) 2000, Elsevier Science Inc.