Pre- and postsynaptic effects of eugenol and related compounds on Helix pomatia L. neurons

Authors
Szabadics, J Erdelyi, L
Citation
J. Szabadics et L. Erdelyi, Pre- and postsynaptic effects of eugenol and related compounds on Helix pomatia L. neurons, ACT BIOL HU, 51(2-4), 2000, pp. 265-273
Citations number
12
Categorie Soggetti
Biology
Journal title
ACTA BIOLOGICA HUNGARICA
ISSN journal
02365383 → ACNP
Volume
51
Issue
2-4
Year of publication
2000
Pages
265 - 273
Database
ISI
SICI code
0236-5383(2000)51:2-4<265:PAPEOE>2.0.ZU;2-I
Abstract
We showed how eugenol blocks the synaptic transmission and gave a possible interpretation how it inhibits the excitation-contraction coupling that sev eral authors described previously [3, 9]. Eugenol acts both in the pre- and postsynaptic side of the neurons. It blocks the Ca2+-currents, decreases t he membrane potential of the neurons, increases the inward resistance and d ecreases the GABA, ACh and glutamate evoked excitatory responses in submill imolar concentration.