INVESTIGATION OF A FUNCTION OF CALCIUM-BINDING PROTEIN P26 (RECOVERIN) IN BOVINE RETINA ROD CELLS

The bovine retina rod cell protein with apparent molecular mass of 26 kD (p26 [1] or recoverin [2]) is suggested to activate guanylate cycla se in a calcium-dependent manner [2,3]. However, according to our pres ent data highly purified preparations of p26 are not able to activate the enzyme. However, we found Ca2+-dependent complex of p26 and a prot ein with apparent molecular mass of 67 kD (presumably the rhodopsin ki nase) in the extract from bovine retina rod outer segments. This sugge sts that rhodopsin kinase may be a functional target for p26 in bovine retina rod cells.