Influence of age and normal plasma fibrinogen levels on flow-mediated dilation in healthy adults

Authors
Allen, JD Wilson, JB Tulley, RT Lefevre, M Welsch, MA
Citation
Jd. Allen et al., Influence of age and normal plasma fibrinogen levels on flow-mediated dilation in healthy adults, AM J CARD, 86(6), 2000, pp. 703
Citations number
16
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF CARDIOLOGY
ISSN journal
00029149 → ACNP
Volume
86
Issue
6
Year of publication
2000
Database
ISI
SICI code
0002-9149(20000915)86:6<703:IOAANP>2.0.ZU;2-O
Abstract
This study examined the effects of age-associated increases in fibrinogen o n brachial artery flow-mediated dilation in 30 healthy nonsmokers. The find ings demonstrate an inverse association between normal plasma fibrinogen le vels and vascular function (r = -0.56, p = 0.001), suggesting elevated plas ma fibrinogen may decrease the artery's responsiveness to certain vasodilat ory signals, such as shear stress.