The clinical performance during first use of a new membrane manufactured fr
om a blend of polyarylethersulfone and polyvinylpyrrolidone (Arylane; Hospa
l Renal Care, Lyon, France), in which the microstructure of the membrane ha
s been tailored by the manufacturing process and polymer blend, has been co
mpared with Fresenius Polysulfone (Fresenius Medical Care, Bad Homburg, Ger
many) in a prospective, randomized, crossover study. Small-molecular cleara
nces were similar. A reduction in plasma beta(2)-microglobulin levels was p
resent using both membranes, with a significantly greater removal by Arylan
e such that the mean postdialysis plasma level difference between the membr
anes at the end of dialysis was 8.7 mg/L (95% confidence interval, 3.9 to 1
3.5; P = 0.004), Recovery of beta(2)-microglobulin from the dialysis fluid
was similar: 170 +/- 70 mg for Arylane and 110 +/- 60 mg for Fresenius Poly
sulfone (P = 0.04), Both membranes were impermeable to albumin but allowed
the passage of low-molecular-weight proteins, with 10,046 +/- 3,239 mg for
Arylane and 7,285 +/- 2,353 mg for Fresenius Polysulfone recovered from the
dialysis fluid (P = 0.07). Neutropenia and platelet adhesion to the membra
ne were minimal, and time-averaged complement levels during dialysis for C3
a and C5b-9 were 207 +/- 92 and 62 +/- 24 ng/mL for Arylane and 223 +/- 68
and 45 +/- 24 ng/mL for Fresenius Polysulfone, respectively, and were membr
ane independent. This study indicates that the membrane using polyarylether
sulfone in conjunction with PVP has complement-activation potential and neu
tropenia similar to Fresenius Polysulfone but has an enhanced capacity to r
emove beta(2)-microglobulin. This enhanced removal arises from transmembran
e transport augmented by adsorption within the membrane matrix. (C) 2000 by
the National Kidney Foundation, Inc.