The number of high-risk patients undergoing renal biopsy is likely to incre
ase in the near future because of the increased use of anticoagulants for s
uch conditions as atrial fibrillation, combined liver and kidney disease ca
used by hepatitis C, and the aging of the population. Nephrologists need to
become increasingly familiar with evaluating such patients through both sp
ecialized management of percutaneous kidney biopsy and alternate methods of
renal biopsy, which primarily consist of open (surgical) biopsy, transjugu
lar (transvenous) biopsy, and laparoscopic biopsy. The indications, complic
ations, and general approach to such patients are discussed. This is a US g
overnment work. There are no restrictions on its use.