Recurrence of the acute HIV syndrome after interruption of antiretroviral therapy in a patient with chronic HIV infection: A case report

Background: Clinical and virologic consequences of temporary interruption o f HIV therapy are incompletely understood. Objective: To describe a febrile illness that was consistent with the acute HIV syndrome and occurred after interruption of antiretroviral therapy. Design: Case report. Setting: University clinic. Patient: HIV-infected man. Measurements: Plasma viral load, lymphocyte subsets, diagnostic evaluation (including cultures and serologic tests), and analysis of lymph node tissue . Results: The patient began antiretroviral therapy 3 months after initial HI V exposure and had sustained viral suppression, except during a brief sched uled treatment interruption. One hundred sixty-nine days after resuming the rapy, the patient discontinued it again immediately following an influenza vaccination. Eleven days later, he presented with a febrile mononucleosis-l ike syndrome associated with dramatic shifts in plasma HIV RNA level (<50 t o >1 000 000 copies/mU and CD4 cell count (0.743 x 10(9) cells/L to 0.086 x 10(9) cells/L). Evaluation for alternative causes of fever was unrevealing . Symptoms resolved rapidly with resumption of HIV therapy. Conclusion: Therapeutic interruption may be associated with profound viral rebound and recurrence of the acute HIV syndrome.