Tamoxifen-induced severe hypertriglyceridemia and pancreatitis

Tamoxifen exhibits favorable effects on the lipid and lipoprotein profile s ince it decreases the total and LDL cholesterol levels as well as the Lp(a) levels. Additionally, a small increase in serum triglycerides is commonly found after tamoxifen administration. However, severe hypertriglyceridemia which can sometimes be associated with life-threatening complications is oc casionally noticed. Herein, we describe a patient who developed tamoxifen-i nduced severe hypertriglyceridemia and pancreatitis. An analysis of the und erlying pathogenetic mechanisms as well as a review of the relevant literat ure is also provided.