Ch. Kao et al., Comparison and discrepancy of 18F-2-deoxyglucose positron emission tomography and Tc-99m MDP bone scan to detect bone metastases, ANTICANC R, 20(3B), 2000, pp. 2189-2192
The purpose of this study was to evaluate the usefulness of positron emissi
on tomography with 18F-2-deoxyglucose (FDG-PET) for the detection of malign
ant bone metastases, and to compare FDC-PET results with conventional techn
etium-99m methylene diophosphate (Tc-99m MDP) bone scan findings. Twenty-fo
ur patients (10 females, 14 males, ages: 39 - 71 years) with biopsy-proven
malignancy and suspected bone metastases, underwent whole body FDG-PET and
bone scan to defect bone metastases. Bone metastases were established in 39
discordant bone lesions by histopathological examination of biopsy samples
, MRI/CT, and follow-tip bone scan/FDG-PET findings showing progressively a
nd extensively widespread bone lesions. A total of 98 bone lesions found on
either FDG-PET or bone scan were evaluated For 39 bone lesions with discor
dant findings between FDG-PET and bone scan, histopathological examination
MRI/CT and follow-up bone scan/FDG-PET findings revealed 8 metastatic and 0
benign bone lesions with positive FDG-PET findings, not detected on bone s
can. Eleven metastatic and 20 benign bone lesions with positive bone scan f
indings were not detected on FDG-PET. FDG-PET has a better specificity, but
a lower sensitivity for detecting malignant bone metastases when compared
with bone scan.