Antimetastatic action of a new analog of dacarbazine in mice bearing Lewislung carcinoma

We report the selective antimetastatic properties of 3(3,3-dimethyl-1-triaz enyl)-5-methyl-4,5-dihydroisoxazole in the murine transplantable tumor mode l Lewis lung carcinoma. The compound verifies a previous study on the corre lation of anti-metastatic, antitumor and cytotoxic properties of aryl- and heteroaryltriazenes with their Electron Ionization Mass Spectrometry (EI-MS ) behavior The new analog of dacarbazine exhibits a selective antimetastati c activity accompanied by limited thymus toxicity. The mechanism of action is unclear nevertheless any antiproliferative or cytotoxic effect is exclud ed.