Effects of triterpenes from the stem bark of Dysoxylum cauliflorum on a non-small-cell bronchopulmonary carcinoma cell line (NSCLC-N-6)

Authors
Benosman, A Richomme, P Roussakis, C Sevenet, T Hadi, AHA Bruneton, J
Citation
A. Benosman et al., Effects of triterpenes from the stem bark of Dysoxylum cauliflorum on a non-small-cell bronchopulmonary carcinoma cell line (NSCLC-N-6), ANTICANC R, 20(3A), 2000, pp. 1855-1859
Citations number
16
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ANTICANCER RESEARCH
ISSN journal
02507005 → ACNP
Volume
20
Issue
3A
Year of publication
2000
Pages
1855 - 1859
Database
ISI
SICI code
0250-7005(200005/06)20:3A<1855:EOTFTS>2.0.ZU;2-P
Abstract
Six triterpenoids and one sesquiterpene were isolated from the ethanolic ex tract of the stem balk of Dysoxylum cauliflorum. Their structures were dete rmined from 1D and 2D NMR and mass spectral data. Only compound I was cytos tatic. Kinetic studies with ethyl eichlerianoate I demonstrated that this g rowth arrest was irreversible and cytofluorimetric analysis with compound I showed a complete block of NSCLC-N-6 cells in the G(1) phase. These events were related to a terminal maturation induction.