Cloning and expression of human adenylyl cyclase type VI in normal thyroidtissues

Authors
Wicker, R Catalan, AG Cailleux, AF Starenki, D Stengel, D Sarasin, A Suarez, HG
Citation
R. Wicker et al., Cloning and expression of human adenylyl cyclase type VI in normal thyroidtissues, BBA-GENE ST, 1493(1-2), 2000, pp. 279-283
Citations number
11
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1493
Issue
1-2
Year of publication
2000
Pages
279 - 283
Database
ISI
SICI code
0167-4781(20000907)1493:1-2<279:CAEOHA>2.0.ZU;2-U
Abstract
The adenylyl cyclase type VI gene expressed in human normal thyroid tissue was cloned and sequenced. The cDNA sequence (6463 nt) is susceptible to cod e for a 1168 aa protein. Northern blots using specific probes showed that t he expression of adenylyl cyclase type VI gene was significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue, in one fo llicular cold adenoma or in one papillary carcinoma. (C) 2000 Elsevier Scie nce B.V. All rights reserved.