Potential antitumor agents. Part 29: Synthesis and potential coanthracyclinic activity of imidazo[2,1-b]thiazole guanylhydrazones

Authors
Andreani, A Leoni, A Locatelli, A Morigi, R Rambaldi, M Recanatini, M Garaliene, V
Citation
A. Andreani et al., Potential antitumor agents. Part 29: Synthesis and potential coanthracyclinic activity of imidazo[2,1-b]thiazole guanylhydrazones, BIO MED CH, 8(9), 2000, pp. 2359-2366
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
8
Issue
9
Year of publication
2000
Pages
2359 - 2366
Database
ISI
SICI code
0968-0896(200009)8:9<2359:PAAP2S>2.0.ZU;2-V
Abstract
This paper reports the synthesis of new imidazo[2,1-b]thiazole guanylhydraz ones which were tested as potential antitumor agents. Three Of these deriva tives (those bearing a 3- or 4-nitrophenyl group) were the most potent and one of these showed a mild effect as CDK I inhibitor. These same three deri vatives were also tested as positive inotropic agents and two of them were more potent than amrinone at 10(- 5) M. These two guanylhydrazones could be useful coanthracyclinic agents. (C) 2000 Elsevier Science Ltd. All rights reserved.