Subretinal fluid levels of topical, oral, and combined administered ciprofloxacin in humans

Aims-To investigate the subretinal fluid (SRF) penetration of ciprofloxacin following topical, oral, and combined administration. Methods-34 patients undergoing conventional retinal reattachment surgery we re randomly assigned to three groups. Twelve patients received topical cipr ofloxacin, 11 patients received oral ciprofloxacin, and the other 11 patien ts received combined drug administration. SRF drug level was measured by us ing high performance liquid chromatography method. Results-The highest drug concentrations of all tested modes were attained f ollowing combined administration and lowest following topical administratio n (p <0.001). The SRF drug concentration following oral administration was also significantly higher than that of topical administration (p <0.001). C oncentrations after oral and combined administration did not differ signifi cantly (p = 0.217). Conclusions-Topical ciprofloxacin can penetrate SRF. Ocular bioavailability of ciprofloxacin in SRF after oral and combined administration is equivale nt.