Type 2 diabetes mellitus in Canada's First Nations: status of an epidemic in progress

THIS REVIEW PROVIDES A STATUS REPORT ON THE EPIDEMIC Of type 2 diabetes mel litus that is affecting many of Canada's First Nations. We focus on the pub lished literature, especially reports published in the past 2 decades, and incorporate data from the Aboriginal Peoples Survey and the First Nations a nd Inuit Regional Health Survey. We look at the extent and magnitude of the problem, the causes and risk factors, primary prevention and screening, cl inical care and education, and cultural concepts and traditional knowledge. The epidemic of type 2 diabetes is still on the upswing, with a trend towa rd earlier age at onset. Genetic-environmental interactions are the likely cause. Scattered intervention projects have been implemented and evaluated, and some show promise. The current health and social repercussions of the disease are considerable, and the long-term outlook remains guarded. A nati onal Aboriginal diabetes strategy is urgently needed.